1 2 Activity - dependent regulation of synaptic strength by 3 PSD - 95 in CA 1 neurons 4 5 6
نویسندگان
چکیده
Brandeis University, Waltham, MA 02454 9 10 11 12 13 14 15 Running title: Activity regulates PSD-95-mediated synaptic strengthening 16 17 Correspondence: John E. Lisman 18 Biology Department and Volen Center for Complex Systems 19 Brandeis University, Waltham, MA 02454 20 E-mail: [email protected] 21 Phone: 781-736-3145 22 Fax: 781-736-3107 23 24 25 Articles in PresS. J Neurophysiol (November 23, 2011). doi:10.1152/jn.00526.2011
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Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neurons.
CaMKII and PSD-95 are the two most abundant postsynaptic proteins in the postsynaptic density (PSD). Overexpression of either can dramatically increase synaptic strength and saturate long-term potentiation (LTP). To do so, CaMKII must be activated, but the same is not true for PSD-95; expressing wild-type PSD-95 is sufficient. This raises the question of whether PSD-95's effects are simply an e...
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